en-sg	Traumatic brain injury (TBI) is usually caused by a blow to the head such as in a car accident or in a fall.
zh-sg	创伤性脑损伤（TBI）通常由头部受击（例如在交通事故或跌倒时）引起。

en-sg	Many people who have a TBI do not survive or, if they do, suffer from long-term disability.
zh-sg	许多遭受 TBI 的人无法存活，即便幸存下来，也会导致长期残疾。

en-sg	Previous studies have shown that about 1,000 people in Australia and New Zealand suffer a moderate or severe TBI every year.
zh-sg	以往的研究表明，澳洲和纽西兰每年约有 1,000人 罹患中度或重度 TBI。

en-sg	With current best available treatment and therapies many of these patients have loss of brain function.
zh-sg	即使采用目前最好的治疗和疗法，许多此类患者仍会丧失脑功能。

en-sg	This can result in varying degrees of long term disability.
zh-sg	这可能导致不同程度的长期残疾。

en-sg	When a patient sustains a traumatic brain injury there are two stages to the injury.
zh-sg	当患者遭受创伤性脑损伤时，损伤会经历两个阶段。

en-sg	The initial impact to the head causes immediate damage to the brain.
zh-sg	最初的头部撞击会造成脑部立即受损。

en-sg	The second stage is the secondary injury phase, and it can evolve over hours or weeks.
zh-sg	第二阶段为继发性损伤阶段，可能在数小时或数周内发生。

en-sg	This stage can cause more damage to the brain.
zh-sg	此阶段可能造成脑部进一步受损。

en-sg	The treatment of brain injury focuses on trying to minimize the secondary injury and there is much research being done to try to find treatments that will prevent it.
zh-sg	脑损伤的治疗侧重于试图尽可能地减少继发性损伤，大量正在进行的研究都希望找到预防继发性损伤的疗法。

en-sg	Patient Information and Consent Form
zh-sg	患者信息及同意书

en-sg	Full Project Title: A randomised, placebo-controlled trial of erythropoietin in ICU patients with traumatic brain injury
zh-sg	完整项目名称： 使用促红细胞生成素治疗创伤性脑损伤 ICU 患者的随机化、安慰剂对照试验

en-sg	ErythroPOietin in Traumatic Brain Injury: "EPO – TBI"
zh-sg	使用促红细胞生成素治疗创伤性脑损伤："EPO – TBI"

en-sg	Principal Investigator: Dr Ng Wai Hoe (NNI) Dr Tan Hui Ling (TTSH)
zh-sg	首席研究员： Ng Wai Hoe 医生（NNI） Tan Hui Ling 医生（TTSH）

en-sg	Sites: National Neuroscience Institute Tan Tock Seng Hospital
zh-sg	地点： 国立脑神经医学院 陈笃生医院

en-sg	11 Jalan Tan Tock Seng
zh-sg	11 Jalan Tan Tock Seng

en-sg	Singapore 308433
zh-sg	Singapore 308433

en-sg	Version number: 1.6 Date: 18 March 2013
zh-sg	版本号： 1.6 日期： 2013 年 3 月 18 日

en-sg	Introduction
zh-sg	简介

en-sg	Please read this information carefully.
zh-sg	请仔细阅读本信息文件。

en-sg	Ask questions about anything that you don't understand or want to know more about.
zh-sg	如果您有不明白的地方或想要了解更多详情，请尽管提问。

en-sg	Before deciding whether or not you should continue to take part, you might want to talk about it with a relative, friend or your local doctor.
zh-sg	在决定患者是否应参加之前，您可能想要与亲属、朋友或您当地的医生讨论。

en-sg	Participation in this research is voluntary.
zh-sg	本研究为自愿参加。

en-sg	If you don't wish to continue to take part, you don't have to.
zh-sg	如果您不希望患者参加，则患者不必参加。

en-sg	You will receive the best possible care whether you continue to take part or not.
zh-sg	不论患者是否参加，都将获得最佳的护理。

en-sg	If you decide that you want to continue to take part in the research project, you will be asked to sign the consent section.
zh-sg	如果您决定让患者参加本研究项目，您将需要签署同意书部分。

en-sg	By signing it you are telling us that you:
zh-sg	签署同意书即表示您：

en-sg	understand what you have read;
zh-sg	理解您所阅读的内容；

en-sg	consent to continuing in the research project;
zh-sg	同意患者参加本研究项目；

en-sg	consent to continuing to have the tests and treatments that are described;
zh-sg	同意患者接受所描述的测试和治疗；

en-sg	consent to the use of your personal and health information as described.
zh-sg	同意让有关方面依据本文件所述的方式使用患者的个人和健康资料。

en-sg	You will be given a copy of this Participant Information and Consent Form (Consent to Continue) to keep.
zh-sg	您将接获一份本《患者信息及同意书（合法代表）》的副本，以供保存。

en-sg	What is the purpose of this research?
zh-sg	本研究的目的是什么？

en-sg	Erythropoietin (EPO) has recently been recognised as a drug that may offer some protection to the brain injured by trauma and help reduce the effects of secondary injury.
zh-sg	促红细胞生成素（EPO）最近被确认为一种可能给受创伤的脑部提供某种保护的药物，并有助于减少继发性损伤的影响。

en-sg	The aim of this study is to determine if EPO reduces secondary brain injury and helps patients make a better recovery after traumatic brain injury.
zh-sg	本研究旨在确定 EPO 是否能够减少继发性脑损伤并帮助患者在遭受创伤性脑损伤之后更好地康复。

en-sg	We also plan to monitor the effect of EPO on the rate of deep vein thrombosis (DVT - blood clots in the large veins, usually in the legs) in patients with moderate or severe TBI in the intensive care unit (ICU).
zh-sg	我们还计划监测 EPO 对于入住重症监护病房（ICU）的中度或重度 TBI 患者深静脉血栓形成（DVT - 大静脉中的血凝块，常见于腿部）发生率的影响。

en-sg	Traumatic brain injury (TBI) is usually caused by a blow to the head such as in a car accident or in a fall. Many people who have a TBI do not survive or, if they do, suffer from long-term disability. Previous studies have shown that about 1,000 people in Australia and New Zealand suffer a moderate or severe TBI every year. With current best available treatment and therapies many of these patients have loss of brain function. This can result in varying degrees of long term disability.
zh-sg	创伤性脑损伤（TBI）通常由头部受击（例如在交通事故或跌倒时）引起。许多遭受 TBI 的人无法存活，即便幸存下来，也会导致长期残疾。以往的研究表明，澳洲和纽西兰每年约有 1,000人 罹患中度或重度 TBI。即使采用目前最好的治疗和疗法，许多此类患者仍会丧失脑功能。这可能导致不同程度的长期残疾。

en-sg	When a patient sustains a traumatic brain injury there are two stages to the injury. The initial impact to the head causes immediate damage to the brain. The second stage is the secondary injury phase, and it can evolve over hours or weeks. This stage can cause more damage to the brain. The treatment of brain injury focuses on trying to minimize the secondary injury and there is much research being done to try to find treatments that will prevent it.
zh-sg	当患者遭受创伤性脑损伤时，损伤会经历两个阶段。最初的头部撞击会造成脑部立即受损。第二阶段为继发性损伤阶段，可能在数小时或数周内发生。此阶段可能造成脑部进一步受损。脑损伤的治疗侧重于试图尽可能地减少继发性损伤，大量正在进行的研究都希望找到预防继发性损伤的疗法。